A child with pituitary gigantism and precocious adrenarche: does GH and/or PRL advance the onset of adrenarche?
| Autor: | Hiroshi Seto, Noritaka Iwatani, Mihoko Kodama |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adenoma
medicine.medical_specialty Hydrocortisone medicine.drug_class Dehydroepiandrosterone Puberty Precocious Biology Dexamethasone Gigantism Endocrinology Internal medicine Etiocholanolone medicine Humans Pituitary Neoplasms Insulin-Like Growth Factor I Child hirsutism Estradiol Dehydroepiandrosterone Sulfate Adrenarche General Engineering Bone age medicine.disease Androgen Growth hormone secretion Prolactin Growth Hormone Pituitary Gland Adrenal Cortex Androgens Female |
| Zdroj: | Endocrinologia japonica. 39(3) |
| ISSN: | 0013-7219 |
| Popis: | We describe a female child with pituitary gigantism and precocious adrenarche. From two years of age she showed unusual overgrowth, and at 5 years old she was 133.5 cm (+ 5.5 SD) tall and weighed 40.5 kg. Her precocious manifestations were public hair, acne vulgaris, hirsutism, and advanced bone age. Endocrinological examination revealed markedly increased serum growth hormone (GH) and prolactin (PRL), which responded paradoxically to a TRH test. In addition, the concentrations of serum dehydroepiandrosterone (DHA) and its sulfate (DHAS) were increased to adult levels, moving in accordance with changes in ACTH, which suggested that these androgens were secreted from the adrenal glands functionally. These androgens seemed to be responsible for her partial precocity. Prior reports have suggested that GH and/or PRL overproduction might have played a role in the induction of adrenarche. Also, in previous reports of 9 gigantism patients under 10 years old, the manifestation of precocious adrenarche was suggested in 8. Further investigation of the influence of GH and PRL on adrenal androgen production in children with pituitary gigantism is required. On the other hand, in short children with normal GH secretion, attention should be paid to whether or not the GH therapy in early childhood induces precocious adrenarche. |
| Databáze: | OpenAIRE |
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