Orchestrated expression of vasculogenic mimicry and laminin‐5γ2 is an independent prognostic marker in oral squamous cell carcinoma

Autor:	Depanwita Saha, Debarpan Mitra, Neyaz Alam, Sagar Sen, Saunak Mitra Mustafi, Syamsundar Mandal, Biswanath Majumder, Nabendu Murmu
Rok vydání:	2022
Předmět:	Neovascularization Pathologic Squamous Cell Carcinoma of Head and Neck Humans Mouth Neoplasms Laminin Original Articles Cell Biology Prognosis Molecular Biology Pathology and Forensic Medicine
Zdroj:	Int J Exp Pathol
ISSN:	1365-2613 0959-9673
DOI:	10.1111/iep.12430
Popis:	Vasculogenic mimicry (VM), an endothelial cell–independent alternative mechanism of blood supply to the malignant tumour, has long been considered as an adverse prognostic factor in many cancers. The correlation of VM with laminin‐5γ2 and the assessment of their harmonized expression as an independent risk factor have not been elucidated yet in oral squamous cell carcinoma (OSCC). CD31/PAS staining stratified 116 clinically diagnosed OSCC specimens into VM+ and VM− cohorts. The expression pattern of laminin‐5γ2 and its upstream modulator MMP2 was evaluated by immunohistochemistry and Western blot. The Kaplan–Meier and Cox regression analyses were performed to assess the survival and prognostic implications. The presence of VM demonstrated a significant correlation with the expression of laminin‐5γ2 (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85395dbdddaf97107ee78fed4d059785 https://doi.org/10.1111/iep.12430 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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