Cardiotoxin III Inhibits Proliferation and Migration of Oral Cancer Cells through MAPK and MMP Signaling
| Autor: | Lo Yi Han, Han Lin Chou, Chien-Chih Chiu, Shih Shin Liang, Shinne-Ren Lin, Chon-Kit Chou, Ching Yu Yen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Article Subject MAP Kinase Signaling System Cobra Cardiotoxin Proteins lcsh:Medicine Cardiotoxin III Biology lcsh:Technology complex mixtures General Biochemistry Genetics and Molecular Biology Metastasis chemistry.chemical_compound Cell Movement Internal medicine Cell Line Tumor medicine Humans Viability assay lcsh:Science General Environmental Science Cell Proliferation Gingival Neoplasms lcsh:T lcsh:R Cancer Cell migration General Medicine medicine.disease Matrix Metalloproteinases Squamous carcinoma Endocrinology chemistry Cancer cell Cancer research lcsh:Q Research Article |
| Zdroj: | The Scientific World Journal, Vol 2013 (2013) The Scientific World Journal |
| DOI: | 10.1155/2013/650946 |
| Popis: | Cardiotoxin III (CTXIII), isolated from the snake venom of Formosan cobraNaja naja atra, has previously been found to induce apoptosis in many types of cancer. Early metastasis is typical for the progression of oral cancer. To modulate the cell migration behavior of oral cancer is one of the oral cancer therapies. In this study, the possible modulating effect of CTXIII on oral cancer migration is addressed. In the example of oral squamous carcinoma Ca9-22 cells, the cell viability was decreased by CTXIII treatment in a dose-responsive manner. In wound-healing assay, the cell migration of Ca9-22 cells was attenuated by CTXIII in a dose- and time-responsive manner. After CTXIII treatment, the MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and p38-MAPK was increased independent of ERK phosphorylation. In conclusion, CTXIII has antiproliferative and -migrating effects on oral cancer cells involving the p38-MAPK and MMP-2/-9 pathways. |
| Databáze: | OpenAIRE |
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