Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation
| Autor: | M A Gougerot-Pocidalo, Didier Payen, C Gatecel, Nathalie Kermarrec, Sylvie Chollet-Martin |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine ARDS Adolescent Neutrophils Respiratory System Agents Macrophage-1 Antigen Nitric Oxide Critical Care and Intensive Care Medicine Neutrophil Activation Proinflammatory cytokine Nitric oxide chemistry.chemical_compound Administration Inhalation Humans Medicine Aged Respiratory Distress Syndrome Lung medicine.diagnostic_test Inhalation Respiratory distress Interleukin-6 business.industry Interleukin-8 Respiratory disease Hydrogen Peroxide Middle Aged medicine.disease Oxygen Pulmonary Alveoli Bronchoalveolar lavage medicine.anatomical_structure Gene Expression Regulation chemistry CD18 Antigens Immunology Cytokines Female business Bronchoalveolar Lavage Fluid |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 153:985-990 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.153.3.8630584 |
| Popis: | It was recently demonstrated that nitric oxide (NO) inhalation improves arterial oxygenation in patients with the adult respiratory distress syndrome (ARDS). However, the potential adverse reaction of NO on inflammatory cells and mediators in the lung has not yet been investigated. In this study, we evaluated the impact of NO inhalation on lung polymorphonuclear neutrophil (PMN) activation and proinflammatory cytokine release, both of which are involved in the pathophysiology of ARDS. Two groups of patients with ARDS of similar etiologies were compared; one received NO (n=9) and the other did not (n=5). After 4 d of NO inhalation (18 ppm), PMN form bronchoalveolar lavage (BAL) showed a reduction in both spontaneous H2O2 production (p |
| Databáze: | OpenAIRE |
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