Heart rate reserve during dipyridamole stress test applied to potential heart donors in brain death
| Autor: | Eugenio Picano, Luciano Potena, Tamara Kovacevic-Preradovic, T. Bombardini, Massimo Maccherini, Davide Pacini |
|---|---|
| Přispěvatelé: | Bombardini T., Pacini D., Potena L., Maccherini M., Kovacevic-Preradovic T., Picano E. |
| Rok vydání: | 2020 |
| Předmět: |
Male
Inotrope Brain Death medicine.medical_specialty Vasodilator Agents Heart rate Coronary Artery Disease Coronary artery disease Electrocardiography Ventricular Dysfunction Left Internal medicine medicine Stress Echocardiography Humans Aged business.industry Dipyridamole Middle Aged medicine.disease Stress echocardiography Blood pressure Marginal donor Tissue donors Exercise Test Cardiology Heart Transplantation Female Cardiology and Cardiovascular Medicine Heart rate reserve business human activities Echocardiography Stress medicine.drug |
| Zdroj: | Minerva Cardioangiologica. 68 |
| ISSN: | 1827-1618 0026-4725 |
| DOI: | 10.23736/s0026-4725.20.05093-8 |
| Popis: | BACKGROUND: A blunted heart rate reserve (HRR) during dipyridamole stress echocardiography (DSE) is a prognostically unfavorable sign of cardiac autonomic dysfunction. Short-term adjustments of heart rate (HR) are thought to rise from changes in neural input to the heart. DSE is applied in potential heart donors to rule out underlying coronary artery disease and left ventricular dysfunction. The aim of this study is to assess HRR during DSE in brain death. METHODS: We enrolled two groups: group 1 (N.=49, 22 men, 54.6±8.8 years) with patients in brain death enrolled in the nationwide marginal donor heart recruiting program; group 2 (N.=49, 18 men, 66.4±12.0 years) referred to DSE for suspected or known coronary artery disease. All underwent DSE (0.84 mg/kg in 6 ) by quality-controlled readers certified via web-based training (1487/CE Lazio-1). We assessed left ventricular contractile reserve (LVCR) as stress/rest ratio of force (systolic blood pressure/end-systolic volume). HRR was calculated as the peak/rest HR ratio from 12-lead EKG. RESULTS: The two study groups were similar for prevalence of inducible ischemia (4/49 vs. 9/49, P=NS). Group 1 showed higher resting HR (group 1: 88.1±15.5 bpm vs. group 2: 66.5±11.5 bpm, P |
| Databáze: | OpenAIRE |
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