Integrins as a drug target in liver fibrosis

Autor: Syedia R. Rahman, James A. Roper, Jane I. Grove, Guruprasad P. Aithal, K. Tao Pun, Andrew J. Bennett
Rok vydání: 2021
Předmět:
Zdroj: Liver international : official journal of the International Association for the Study of the LiverREFERENCES. 42(3)
ISSN: 1478-3231
1478-3223
Popis: As the worldwide prevalence of chronic liver diseases is high and continuing to increase, there is an urgent need for treatment to prevent cirrhosis-related morbidity and mortality. Integrins are heterodimeric cell-surface proteins that are promising targets for therapeutic intervention. ?v integrins are central in the development of fibrosis as they activate latent TGF?, a known profibrogenic cytokine. The ?v subunit can form heterodimers with ?1, ?3, ?5, ?6 or ?8 subunits and one or more of these integrins are central to the development of liver fibrosis, however, their relative importance is not understood. This review summarises the current knowledge of ?v integrins and their respective ? subunits in different organs, with a focus on liver fibrosis and the emerging preclinical and clinical data with regards to ?v integrin inhibitors.
Databáze: OpenAIRE
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