Treatment of Malignant Glioma with High Dose Intra-arterial ACNU and Autologous Bone Marrow Transplantation
| Autor: | Takashi Fujiwara, Junji Yoshioka, Takashi Ohmoto |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Glycerol Pathology medicine.medical_specialty Encephalopathy Urology Brain Edema Astrocytoma Glioma Intra arterial Humans Medicine Bone Marrow Transplantation Brain Neoplasms business.industry Marrow transplantation Neurotoxicity Malignant astrocytoma Autologous bone medicine.disease Combined Modality Therapy Thrombocytopenia Frontal Lobe Nimustine Injections Intra-Arterial Bone marrow suppression Female Surgery Neurology (clinical) Neoplasm Recurrence Local business Agranulocytosis |
| Zdroj: | Neurologia medico-chirurgica. 31:654-657 |
| ISSN: | 1349-8029 0470-8105 |
| DOI: | 10.2176/nmc.31.654 |
| Popis: | A 44-year-old female with malignant astrocytoma received subtotal removal and high dose (200 mg/m2) intra-arterial 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloroethyl)-3-nitrosourea hydrochloride (ACNU) with autologous bone marrow transplantation. Tumor remission with minimal bone marrow suppression was achieved. However, she developed severe encephalopathy and computed tomographic scans revealed a low-density area at the ACNU delivery site. She received glycerol solution to treat the brain edema and recovered completely from the encephalopathy. Intra-arterial ACNU exceeding 200 mg/m2 possibly causes neurotoxicity. |
| Databáze: | OpenAIRE |
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