Normal Bone Microstructure and Density But Worse Physical Function in Older Women Treated with Selective Serotonin Reuptake Inhibitors, a Cross-Sectional Population-Based Study

Autor: Anna G Nilsson, Lisa Johansson, Daniel Sundh, Mattias Lorentzon, B. Larsson, Dan Mellström
Jazyk: angličtina
Rok vydání: 2018
Předmět:
medicine.medical_specialty
Bone density
Endocrinology
Diabetes and Metabolism
Population
030209 endocrinology & metabolism
Osteoporotic fracture
Bone and Bones
03 medical and health sciences
Grip strength
0302 clinical medicine
Endocrinology
Fall-related injury
Bone Density
medicine
SSRI
Humans
Orthopedics and Sports Medicine
030212 general & internal medicine
Quantitative computed tomography
education
Exercise
Femoral neck
Original Research
Aged
Bone mineral
Aged
80 and over
education.field_of_study
medicine.diagnostic_test
Hand Strength
business.industry
Walking Speed
Preferred walking speed
medicine.anatomical_structure
Cross-Sectional Studies
Bone microstructure
Physical Fitness
Orthopedic surgery
Physical therapy
Physical function
Female
business
Selective Serotonin Reuptake Inhibitors
Zdroj: Calcified Tissue International
ISSN: 1432-0827
0171-967X
Popis: Depression in the elderly is today often treated with selective serotonin reuptake inhibitors (SSRIs) because of their favorable adverse effect profile. However, treatment with SSRIs is associated with increased risk of fractures. Whether this increased risk depends on reduced bone strength or increased fall risk due to reduced physical function is not certain. The aim was therefore to investigate if treatment with SSRIs is associated with impaired bone microstructure, bone density, or physical function in older women. From an ongoing population-based study, 1057 women (77.7 ± 1.5 years) were included. Validated questionnaires were used to assess information regarding medical history, medications, smoking, mental and physical health, and physical activity. Physical function was measured using clinically used tests: timed up and go, walking speed, grip strength, chair stand test, and one leg standing. Bone mineral density (BMD) was measured at the hip and spine with dual-energy X-ray absorptiometry (Hologic Discovery A). Bone geometry and microstructure were measured at the ultradistal and distal (14%) site of radius and tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeCT). Treatment with SSRIs was associated with higher BMD at the femoral neck, total hip, and lumbar spine, whereas no associations were found for any HR-pQCT-derived measurements. The use of SSRIs was associated with lower grip strength, walking speed, and fewer chair stand rises. These associations were valid also after adjustments for known risk factors for falls. Treatment with SSRIs was, independently of covariates, associated with worse physical function without any signs of inferior bone geometry and microstructure. Electronic supplementary material The online version of this article (10.1007/s00223-018-0427-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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