Distinct association of plasma BDNF concentration and cognitive function in depressed patients treated with vortioxetine or escitalopram

Autor: Alma Mihaljević-Peleš, Anja Dvojkovic, Zorana Kušević, Nenad Jakšić, Nela Pivac, Maja Zivkovic, Marina Šagud, Matea Nikolac Perkovic, Bjanka Vuksan-Ćusa
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
vortioxetine
escitalopram
cognition
memory
executivefunction
BDNF
depression
MDD
Adolescent
Depressive Disorder
Major / drug therapy
Memory
Short-Term / drug effects
Brain-Derived Neurotrophic Factor / blood
Citalopram
03 medical and health sciences
Young Adult
0302 clinical medicine
Cognition
Citalopram / therapeutic use
Internal medicine
mental disorders
Vortioxetine / therapeutic use
Memory span
medicine
Verbal fluency test
Escitalopram
Humans
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Aged
Antidepressive Agents / therapeutic use
Pharmacology
Vortioxetine
Cognitive Dysfunction / drug therapy
Depressive Disorder
Major
Working memory
business.industry
Brain-Derived Neurotrophic Factor
Middle Aged
medicine.disease
Antidepressive Agents
030227 psychiatry
Endocrinology
Memory
Short-Term
Cognition / drug effects
Major depressive disorder
Female
business
030217 neurology & neurosurgery
medicine.drug
Zdroj: Psychopharmacology. 238(6)
ISSN: 1432-2072
Popis: Rationale: Cognitive dysfunction is frequent in major depressive disorder (MDD), and brain-derived neurotrophic factor (BDNF) is involved both in regulation of cognition and in therapeutic response in MDD. ----- Objectives: The aim of this study was to determine if baseline plasma BDNF might predict change in cognitive function in MDD patients treated with vortioxetine or escitalopram, and whether the alterations in BDNF levels correlate with changes in cognitive performance during treatment. ----- Methods: Drug-naive or drug-free patients with MDD (N=121) were sampled and evaluated at baseline and 4 weeks after treatment initiation with vortioxetine or escitalopram. Cognitive function was evaluated using the F-A-S test, Digit Span test, and Digit Symbol Coding test. Plasma BDNF was determined using ELISA. ----- Results: The results of the study indicate that both vortioxetine (V) and escitalopram (E) improved cognitive functions evaluated with F-A-S test (V: p
Databáze: OpenAIRE
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