SIC: an intracerebral radiosensitive probe for in vivo neuropharmacology investigations in small laboratory animals: prototype design, characterization, and in vivo evaluation
| Autor: | Vincent Leviel, Philippe Hantraye, P. Laniece, Frédéric Pain, A. Glatigny, Laurent Ménard, L. Valentin, L. Pinot, Y. Charon, R. Mastrippolito, M.T. Guillemin |
|---|---|
| Přispěvatelé: | Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11) |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Nuclear and High Energy Physics
Microprobe Microdialysis Materials science [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] 030218 nuclear medicine & medical imaging Characterization (materials science) 03 medical and health sciences 0302 clinical medicine Nuclear Energy and Engineering In vivo Small animal Temporal resolution In vivo measurements CTD Electrical and Electronic Engineering 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | IEEE Transactions on Nuclear Science IEEE Transactions on Nuclear Science, Institute of Electrical and Electronics Engineers, 2002, 49, pp.822-826 HAL |
| ISSN: | 0018-9499 |
| Popis: | Several high-resolution tomographs dedicated to small animal imaging are presently under development. However, these devices suffer from two major drawbacks: their cost is high and require animal anaesthesia and immobilization thus restricting the field of investigations. Therefore, the authors have proposed SIC (French acronym for "Sonde IntraCerebrale") a low cost beta microprobe able to count the radioactivity concentration locally in awake, freely moving animals. Beside a good sensitivity, this tool offers the advantage of a high temporal resolution, a major asset for in vivo measurements of tracer kinetics. Furthermore, it could be easily coupled with existing techniques such as electrophysiology, microdialysis, voltametry and magnetic resonance imaging thus providing simultaneously complementary information on the cerebral mechanisms. The authors present here the design, manufacture and first evaluations of a first prototype. A first in vitro evaluation using a simple beaker filled with an homogenous aqueous solution of [/sup 18/F]-fluorodeoxyglucose (FDG) confirmed the authors' first simulation results in terms of sensitivity and detection volume. Then, further experimentation carried out in vivo on anaesthetized rats bearing two implanted probes in the brain have validated the use of SIC to measure locally, with a high temporal resolution, the concentration of radiolabeled molecules in living rodents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|