The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection
| Autor: | Martin Lagging, Kristine Mørch, Nina Langeland, Kristina Nyström, Gunnar Norkrans, Jesper Waldenström, Johan Westin, Magdalena Ydreborg, Staffan Nilsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
RNA viruses
Liver Cirrhosis Male Steatosis Biopsy Denmark Organic chemistry Hepacivirus Gastroenterology Body Mass Index Cytopathology Liver disease 0302 clinical medicine Fibrosis Genotype Ethnicity Vitamin D Immune Response Pathology and laboratory medicine Finland Multidisciplinary medicine.diagnostic_test Hepatitis C virus Norway Liver Diseases Vitamins Medical microbiology Middle Aged Physical sciences Europe Chemistry Cirrhosis Liver Liver biopsy Viruses Medicine Liver Fibrosis Regression Analysis 030211 gastroenterology & hepatology Female Seasons Pathogens Research Article Adult medicine.medical_specialty Science Immunology 030209 endocrinology & metabolism Gastroenterology and Hepatology Microbiology 03 medical and health sciences Chemical compounds Signs and Symptoms Internal medicine Organic compounds medicine Vitamin D and neurology Humans Medicine and health sciences Inflammation Sweden Polymorphism Genetic Flaviviruses business.industry Organisms Viral pathogens Biology and Life Sciences Hepatitis C Chronic medicine.disease Hepatitis viruses Microbial pathogens Fatty Liver Anatomical Pathology Histopathology Clinical Medicine business Hepatic fibrosis Developmental Biology |
| Zdroj: | PLoS ONE e0237840 PLOS ONE 15:e0237840 PLoS ONE, Vol 15, Iss 8, p e0237840 (2020) |
| ISSN: | 1932-6203 |
| Popis: | Background and objectivesThe hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy.Method25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated.ResultsMean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values ConclusionFibrosis was not independently associated with 25(OH)D concentration and no association was seen with hepatic inflammation, but HCV genotype 2 infected patients with moderate-to-severe steatosis had lower 25(OH)D levels compared to those without steatosis. A high percentage had potential risk of 25(OH)D deficiency, and BMI, seasonality and ethnicity were independently associated with 25(OH)D as previously reported. |
| Databáze: | OpenAIRE |
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