Detection of Pulmonary Embolism with Gallium-68 Macroaggregated Albumin Perfusion PET/CT: An Experimental Study in Rabbits
| Autor: | Ayşe Uğur, Ferda Bir, Mustafa Cagdas Cayir, Aziz Gültekin, Doğangün Yüksel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
gallium 68
Perfusion scanning 030218 nuclear medicine & medical imaging 0302 clinical medicine medical examination Positron Emission Tomography Computed Tomography nuclear medicine macroaggregated albumin ga 68 single photon emission computed tomography-computed tomography Pulmonary embolism unclassified drug Perfusion medicine.anatomical_structure priority journal 030220 oncology & carcinogenesis histopathology Macroaggregated albumin diagnostic accuracy sham procedure Rabbits lung embolism Research Article Article Subject animal experiment Leporidae Article experimental study animal tissue 03 medical and health sciences Animal model Organometallic Compounds medicine Medical technology Animals Radiology Nuclear Medicine and imaging controlled study diagnostic test accuracy study R855-855.5 Serum Albumin albumin Tomography Emission-Computed Single-Photon PET-CT Lung nonhuman business.industry animal model reference value medicine.disease lung ventilation sensitivity and specificity Rabbit model Pulmonary Embolism Nuclear medicine business |
| Zdroj: | Contrast Media & Molecular Imaging, Vol 2020 (2020) Contrast Media & Molecular Imaging |
| ISSN: | 1555-4317 1555-4309 |
| Popis: | Purpose To evaluate the use of gallium-68 ( 68 Ga) macroaggregated albumin (MAA) positron emission tomography/computed tomography (PET/CT) perfusion imaging combined with Technegas single-photon emission computed tomography/computed tomography (SPECT/CT) ventilation imaging in rabbits with experimental pulmonary emboli (PE). Methods Technegas SPECT/CT ventilation and a 68 Ga-MAA PET/CT perfusion scan (V/Q scan) were performed in 12 rabbits before and one hour after artificial induction of PE. Technegas SPECT/CT and 68 Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68 Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. Results A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68 Ga-MAA PET/CT V/Q scans. Conclusion Technegas/ 68 Ga-MAA V/Q scans have good sensitivity, specificity and accuracy in the detection of PE in this animal model study. |
| Databáze: | OpenAIRE |
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