Advancement in Stem Cell Therapy for Ischemic Myocardial Cell: A Systematic Review
| Autor: | Syeda Beenish Bareeqa, Syed Ijlal Ahmed, Fazeela Bibi, Syeda Sana Samar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Review Article lcsh:RC254-282 03 medical and health sciences Therapeutic approach Medicine Myocardial infarction Intensive care medicine Cardiomyocytes Transplantation business.industry Mesenchymal stem cell Hematology Stem-cell therapy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Clinical trial Mesenchymal stem cells (MSCs) Myocardial infarction (MI) Cardiomyocytes Hematopoietic stem cells (HSCs) 030104 developmental biology Oncology Mesenchymal stem cells Stem cell business Hematopoietic stem cells Medical literature |
| Zdroj: | International Journal of Hematology-Oncology and Stem Cell Research International Journal of Hematology-Oncology and Stem Cell Research, Vol 12, Iss 4 (2018) |
| ISSN: | 2008-3009 |
| Popis: | Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique. Twenty cases of mammalian animals and twenty-four cases of stem cell transplantation in human subjects were reviewed. Results: Most common associated complication was re-stenosis of coronary artery. Few clinical trials reported the failure in improving cardiac functioning. The success rate of stem cell transplantation was remarkable in the literature related to experimental animal subjects. Conclusion: It was concluded that renewal of the cardiac cell is a result of induction of angiogenesis and prolonged cell survival. This topic still requires an immense amount of research to fill the gap in adequate knowledge. Keywords: Mesenchymal stem cells, Myocardial infarction, Cardiomyocytes, Hematopoietic stem cells |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|