Acute and Chronic Cutaneous Reactions to Ionizing Radiation Therapy
| Autor: | Aaron H. Wolfson, Brian J. Simmons, Fleta N. Bray, Keyvan Nouri |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Radiation burns Radiation dermatitis Review Dermatology Acute Ionizing radiation Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Quality of life Fibrosis medicine Chronic Adverse effect business.industry Radiation recall medicine.disease Surgery Radiation therapy 030220 oncology & carcinogenesis Oral and maxillofacial surgery Etiology Radiation skin toxicity business |
| Zdroj: | Dermatology and Therapy |
| ISSN: | 2190-9172 2193-8210 |
| DOI: | 10.1007/s13555-016-0120-y |
| Popis: | Ionizing radiation is an important treatment modality for a variety of malignant conditions. However, development of radiation-induced skin changes is a significant adverse effect of radiation therapy (RT). Cutaneous repercussions of RT vary considerably in severity, course, and prognosis. When they do occur, cutaneous changes to RT are commonly graded as acute, consequential-late, or chronic. Acute reactions can have severe sequelae that impact quality of life as well as cancer treatment. Thus, dermatologists should be informed about these adverse reactions, know how to assess their severity and be able to determine course of management. The majority of measures currently available to prevent these acute reactions are proper skin hygiene and topical steroids, which limit the severity and decrease symptoms. Once acute cutaneous reactions develop, they are treated according to their severity. Treatments are similar to those used in prevention, but incorporate wound care management that maintains a moist environment to hasten recovery. Chronic changes are a unique subset of adverse reactions to RT that may develop months to years following treatment. Chronic radiation dermatitis is often permanent, progressive, and potentially irreversible with substantial impact on quality of life. Here, we also review the etiology, clinical manifestations, pathogenesis, prevention, and management of late-stage cutaneous reactions to radiotherapy, including chronic radiation dermatitis and radiation-induced fibrosis. |
| Databáze: | OpenAIRE |
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