Treatment of cutaneous basal cell carcinoma with combined laser extirpation and methyl aminolevulinic acid: five-year success rates
| Autor: | Matteo Tretti Clementoni, Christopher Henry Barbara, B. O’Leary, W. Abdelrahman, N. Miles, Maxwell Murison, Liberato Camilleri, Ernest A. Azzopardi, Elayne Azzopardi, Jeremy Yarrow |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Cost-Benefit Analysis medicine.medical_treatment Dermatologic Surgical Procedures Urology Photodynamic therapy 030230 surgery 03 medical and health sciences 0302 clinical medicine Laser therapy medicine Humans Basal cell carcinoma Aged Retrospective Studies Aged 80 and over Photosensitizing Agents business.industry Cancer Aminolevulinic Acid General Medicine Middle Aged medicine.disease Combined Modality Therapy United Kingdom Treatment Outcome Photochemotherapy Carcinoma Basal Cell Lasers Gas Female Surgery business Clearance rate Follow-Up Studies |
| Zdroj: | The Annals of The Royal College of Surgeons of England. 103:263-271 |
| ISSN: | 1478-7083 0035-8843 |
| DOI: | 10.1308/rcsann.2020.7020 |
| Popis: | Introduction Basal cell carcinoma is the most common cancer. Excisional surgery is associated with a high clearance rate, at the expense of significant functional and aesthetic morbidity, especially within the T-zone or for extensive lesions. We report five-year follow-up outcomes for carbon dioxide laser extirpation of cutaneous basal cell carcinoma, assisted by immediate methyl aminolevulinate photodynamic therapy and cost–benefit considerations. Materials and methods Retrospective cohort database analysis of adult patients with biopsy-proven primary cutaneous basal cell carcinoma, completing five years of follow-up. Direct per-lesion cost was compared with conventional wide local excision. Patients with morphoeic basal cell carcinoma were excluded. Results Treated lesions were up to 1% total body surface area and up to 3.8mm (1.38 ± 0.695cm, mean ± standard deviation) in biopsy-proven depth. At the five-year follow-up mark, 93.6% of treated areas remained free of recurrence. Nodular basal cell carcinoma was the most common subtype (41.5%). A mean tumour depth greater than 2 ± 0.872mm was significantly associated with recurrence (Mann–Whitney, p = 0.0487). For a service delivered through the NHS at 2015 prices, we report a 43% saving, equating to a saving of £235 per basal cell carcinoma or a national annualised saving of £70 million by 2025 for the NHS. Conclusion Our results suggest that CO2-assisted photodynamic therapy is non-inferior to excision but may offer better functional and cosmetic preservation at a fraction of the direct like for like cost of operative surgery. Investigation of this method by randomised controlled methodology is warranted. |
| Databáze: | OpenAIRE |
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