Determination of dihydroergotamine in human plasma by high-performance liquid chromatography with fluorescence detection
| Autor: | Michelle Murday, Richard A. Couch, Angus M. McLean, Elizabeth Slaughter |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Chromatography
Chemistry Alkaloid Antagonist Reproducibility of Results General Chemistry High-performance liquid chromatography Fluorescence Dihydroergotamine Fluorescence spectroscopy Spectrometry Fluorescence Blood plasma medicine Humans Quantitative analysis (chemistry) Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 735:151-157 |
| ISSN: | 0378-4347 |
| Popis: | Dihydroergotamine, a 5-hydroxytryptamine antagonist, is used for the treatment of vascular headaches. A high-performance liquid chromatography assay with fluorescence detection is described for the determination of dihydroergotamine in plasma. The assay was validated over the concentration range 0.1-10 ng/ml plasma and applied to the analysis of plasma samples from subjects treated intramuscularly and intranasally with 2 mg of dihydroergotamine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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