Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson’s Disease
| Autor: | Howard M. Cooper, Kwamivi Dzahini, Colette Dehay, Virginie Dolmazon, Karim Fifel, Julien Vezoli, Pierre Misery, Pierre Savatier, Charles R.E. Wilson, Florence Wianny, Camille Lamy, Emmanuel Procyk, Agnieszka Bernat, Henry Kennedy |
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| Přispěvatelé: | Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (U1208 Inserm - UCBL1 / SBRI - USC 1361 INRAE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité sous contrat plate-forme biotechnologique de cellules souches plate-forme PrimaStem, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Chinese Academy of Sciences [Beijing] (CAS), Ernst Strüngmann Institute for Neuroscience in Cooperation (ESI), Max-Planck-Gesellschaft |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Parkinson's disease
General Chemical Engineering Dopamine [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology General Physics and Astronomy Medicine (miscellaneous) Disease Biochemistry Genetics and Molecular Biology (miscellaneous) Macaque 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine biology.animal Basal ganglia medicine Animals Humans General Materials Science Cognitive Dysfunction Longitudinal Studies 030304 developmental biology 0303 health sciences biology business.industry MPTP Dopaminergic General Engineering Parkinson Disease Cognition medicine.disease Transplantation chemistry Macaca business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Advanced Science |
| Popis: | Parkinson’s disease (PD) evolves over an extended and variable period in humans; several years prior to the onset of classical motor symptoms, cognitive deficits as well as sleep and biological rhythm disorders develop and worsen with disease progression, significantly impacting the quality of life of patients. The gold standard MPTP macaque model of PD recapitulates the progression of motor and non-motor symptoms over contracted periods of time.Here, this multidisciplinary and multiparametric study follows, in five animals, the steady progression of motor and non-motor symptoms and describes their reversal following bilateral grafts of neural precursors in diverse functional domains of the basal ganglia.Results show unprecedented recovery from cognitive symptoms in addition to a strong clinical motor recuperation. Both motor and cognitive recovery and partial circadian rhythm recovery correlate with the degree of graft integration into the host environment as well as with in-vivo levels of striatal dopaminergic innervation and function.Given inter-individuality of disease progression and recovery the present study underlines the importance of longitudinal multidisciplinary assessments in view of clinical translation and provides empirical evidence that integration of neural precursors following transplantation efficiently restores function at multiple levels in parkinsonian non-human primates.One Sentence SummaryEmpirical evidence that cell therapy efficiently reverts cognitive and clinical motor symptoms in the non-human primate model of Parkinson’s disease. |
| Databáze: | OpenAIRE |
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