Extended Allograft Survival of Islets Grafted into Intra-abdominally Placed Testis
| Autor: | Helena P. Selawry, Karen Whittington |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Islets of Langerhans Transplantation Abdominal cavity Testicle Kidney Renal capsule Internal medicine Testis Scrotum Internal Medicine medicine Animals Transplantation Homologous geography geography.geographical_feature_category business.industry Graft Survival Rats Inbred Strains Immunosuppression Islet Rats Transplantation medicine.anatomical_structure Endocrinology Liver Abdomen Female business |
| Zdroj: | Diabetes. 33:405-406 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.33.4.405 |
| Popis: | Isolated islets of ACI donor rats were cultured for 4 days at 37°C and then grafted into male diabetic Wistar-Lewis rats into three different organ sites without adjuvant immunosuppression. None of 6 recipients of the intraportal injection of 10 islets per gram of body weight became normoglycemic. Similarly, six rats that received islets injected under the renal capsule remained diabetic. None of six rats that received an intratesticular islet allograft became normoglycemic while these organs remained within the scrotum. By contrast, six rats that were transplanted with an identical number of islets into the testis, which were then surgically placed into the abdominal cavity, promptly became aglycosuric and have remained so for more than 50 days. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|