Regulation of neutrophils in type 2 immune responses
| Autor: | Lukas E. M. Heeb, Daniela Impellizzieri, Cecilie Egholm, Onur Boyman, Frederike Ridder |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neutrophils medicine.medical_treatment Immunology 610 Medicine & health Biology Inhibitory postsynaptic potential 03 medical and health sciences Th2 Cells Immune system medicine Animals Humans Immunology and Allergy Receptor Receptors Interleukin-4 Type II Interleukin 4 2403 Immunology Target tissue Allergic asthma 030104 developmental biology Cytokine 10033 Clinic for Immunology 2723 Immunology and Allergy Neutrophil recruitment |
| Zdroj: | Current Opinion in Immunology. 54:115-122 |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/j.coi.2018.06.009 |
| Popis: | Type 2 immune responses contribute to the resistance to helminths and toxins as well as several physiological processes. Although they usually do not participate in type 2 immune responses, neutrophils have been shown in mice to enhance the anti-helminth response, but they also contribute to increased target tissue damage. Increased pathology and morbidity is also observed in type 2 immune-mediated disorders, such as allergic asthma, when neutrophils become a predominant subset of the infiltrate. How neutrophil recruitment is regulated during type 2 immune responses is now starting to become clear, with recent data showing that signaling via the prototypic type 2 cytokine interleukin-4 receptor mediates direct and indirect inhibitory actions on neutrophils in mice and humans. |
| Databáze: | OpenAIRE |
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