Internalized Functional DNA Aptamers as Alternative Cancer Therapies
| Autor: | Kylie M. Wagstaff, Morgan L Marshall |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
tumor-specific precision medicine Aptamer media_common.quotation_subject DNA-aptamer Review Computational biology Disease DNA Aptamers Biology 03 medical and health sciences 0302 clinical medicine medicine nanoparticle-free Pharmacology (medical) Internalization media_common Pharmacology lcsh:RM1-950 Cancer Precision medicine medicine.disease Small molecule lcsh:Therapeutics. Pharmacology 030104 developmental biology 030220 oncology & carcinogenesis intracellular targeting Intracellular |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| ISSN: | 1663-9812 |
| Popis: | Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern healthcare requirements, it is essential to develop precision therapeutics that minimise off-target side-effects for various cancer types. To this end, highly specific molecular targeting agents against cancer are of great interest. These agents may work by targeting intracellular signalling pathways following receptor binding, or via internalization and targeting to specific subcellular compartments. DNA aptamers represent a promising molecular tool in this arena that can be used for both specific cell surface targeting and subsequent internalization and can also elicit a functional effect upon internalization. This review examines various cancer targeting cell-internalizing aptamers, with a particular focus towards functional aptamers that do not require additional conjugation to nanoparticles or small molecules to elicit a biological response. With a deeper understanding and precise exploitation of cancer specific molecular pathways, functional intracellular DNA aptamers may be a powerful step towards more widespread development of precision therapeutics. |
| Databáze: | OpenAIRE |
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