Redox imbalance caused by pesticides: a review of OPENTOX-related research
| Autor: | Davor Želježić, Ana Marija Marjanović Čermak, Ivan Pavičić |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
010501 environmental sciences Cellular level Biology Cell Enlargement In Vitro Techniques Toxicology medicine.disease_cause 01 natural sciences Redox Pesticide toxicity 03 medical and health sciences antioxidants apoptosis glyphosate in vitro neonicotinoids organophosphates oxidative stress pyrethroids reactive oxygen species medicine Animals Pesticides 0105 earth and related environmental sciences Cell Proliferation Pollutant business.industry Public Health Environmental and Occupational Health Pesticide people.cause_of_death Biotechnology Oxidative Stress 030104 developmental biology antioksidansi apoptoza glifosat neonikotinoidi organofosfati oksidacijski stres piretroidi reaktivni kisikovi spojevi Toxicity Related research business people Oxidation-Reduction Oxidative stress Biomarkers |
| Zdroj: | Arhiv za higijenu rada i toksikologiju Volume 69 Issue 2 |
| ISSN: | 1848-6312 0004-1254 |
| Popis: | Pesticides are a highly diverse group of compounds and the most important chemical stressors in the environment. Mechanisms that could explain pesticide toxicity are constantly being studied and their interactions at the cellular level are often observed in well-controlled in vitro studies. Several pesticide groups have been found to impair the redox balance in the cell, but the mechanisms leading to oxidative stress for certain pesticides are only partly understood. As our scientific project “Organic pollutants in environment – markers and biomarkers of toxicity (OPENTOX)” is dedicated to studying toxic effects of selected insecticides and herbicides, this review is focused on reporting the knowledge regarding oxidative stress-related phenomena at the cellular level. We wanted to single out the most important facts relevant to the evaluation of our own findings from studies conducted on in vitro cell models. Pesticidi su raznovrsna skupina spojeva i glavni izvor stresa u okolišu. Mehanizmi kojima se nastoji objasniti toksičnost pesticida kontinuirano se istražuju, a njihove interakcije na staničnoj razini često se promatraju u sklopu kontroliranih in vitro istraživanja. Za nekoliko skupina pesticida utvrđeno je da narušavaju oksidacijsko-redukcijsku ravnotežu u stanici, a mehanizmi koji vode do nastanka oksidacijskoga stresa za pojedine su pesticide još uvijek nedovoljno poznati. Budući da je naš znanstveni projekt „Organska zagađivala u okolišu-markeri i biomarkeri toksičnosti (OPENTOX)“ posvećen istraživanju toksičnih učinaka odabranih insekticida i herbicida, ovaj pregledni rad usmjeren je na prikaz spoznaja koje se odnose na promjene uzrokovane stresom na staničnoj razini. Željeli smo izdvojiti najvažnije činjenice koje su bitne za procjenu vlastitih rezultata istraživanja provedenih na in vitro staničnim modelima. |
| Databáze: | OpenAIRE |
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