Use of Imaging to Predict Complete Response of Colorectal Liver Metastases after Chemotherapy: MR Imaging versus CT Imaging
| Autor: | Hye Jin Kim, Mi-Suk Park, Sung Eun Rha, Chung Mo Nam, Chang Hee Lee, Sumi Park, Chansik An, Honsoul Kim, Nurhee Hong, Won Jae Lee, Yang Shin Park, Seong Ho Park, Yoonjin Lee, Min Ju Kim, Kyunghwa Han, Min Jung Park |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty medicine.medical_treatment Contrast Media Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Unresected Predictive Value of Tests Statistical significance medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies Chemotherapy medicine.diagnostic_test business.industry Liver Neoplasms Magnetic resonance imaging Retrospective cohort study Middle Aged Magnetic Resonance Imaging Confidence interval Treatment Outcome 030220 oncology & carcinogenesis Predictive value of tests Catheter Ablation Female Tomography Radiology business Colorectal Neoplasms Tomography X-Ray Computed |
| Zdroj: | Radiology. 284(2) |
| ISSN: | 1527-1315 |
| Popis: | Purpose To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrast-enhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled. The anonymized imaging data and case report forms were sent to the central review system and independently reviewed by four radiologists. All anonymized data were randomly allocated into two groups (groups A and B), which were read by two independent readers. True absence of tumor was defined as pathologic absence of tumor for resected lesions and no in situ recurrence within 1 year after surgery for lesions left unresected at each 3-month follow-up contrast-enhanced CT. Positive predictive values for absence of tumor and for residual tumor on contrast-enhanced CT and EOB MR images were compared by using a generalized estimating equation. Results Among 393 CRLMs, the positive predictive value for absence of tumor on EOB MR images (78.0%; 95% confidence interval [CI]: 63.68%, 87.74%) was significantly higher than that on contrast-enhanced CT scans (35.2%; 95% CI: 25.11%, 46.79%; P < .001). The positive predictive value for residual tumor on CT scans (86.0%; 95% CI: 78.61%, 91.16%) was higher than that on EOB MR images (83.8%; 95% CI: 77.50%, 88.67%) without statistical significance (P = .330). Conclusion EOB MR imaging was superior to contrast-enhanced CT imaging for assessment of disappearing CRLMs after chemotherapy. © RSNA, 2017 Online supplemental material is available for this article. |
| Databáze: | OpenAIRE |
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