The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin
| Autor: | Hiroki Kittaka, Makoto Tominaga |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Long lasting lcsh:Immunologic diseases. Allergy INSECT BITES Sensory Receptor Cells Sensory system Itch TRPA1 03 medical and health sciences Transient receptor potential channel Cutaneous sensation 0302 clinical medicine Transient Receptor Potential Channels Basic research immune system diseases parasitic diseases otorhinolaryngologic diseases Medicine Humans Immunology and Allergy Peripheral Nerves Chronic itch skin and connective tissue diseases Skin business.industry Pruritus General Medicine eye diseases Peripheral TRPV1 030104 developmental biology TRPV3 TRPV4 Immunology business lcsh:RC581-607 030217 neurology & neurosurgery |
| Zdroj: | Allergology International, Vol 66, Iss 1, Pp 22-30 (2017) |
| ISSN: | 1323-8930 |
| DOI: | 10.1016/j.alit.2016.10.003 |
| Popis: | Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations are thought to protect against external insults and toxic substances. Although itch is not directly lethal, chronic and long lasting itch in certain diseases can worsen quality of life. Therefore, the mechanisms responsible for chronic itch require careful investigation. There is a significant amount of basic research concerning itch, and the effect of various itch mediators on primary sensory neurons have been studied. Interestingly, many mediators of itch involve signaling related to transient receptor potential (TRP) channels. TRP channels, especially thermosensitive TRP channels, are expressed by primary sensory neurons and skin keratinocytes, which receive multimodal stimuli, including those that cause itch sensations. Here we review the molecular and cellular mechanisms of itch and the involvement of TRP channels in mediating itch sensations. |
| Databáze: | OpenAIRE |
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