The myofibroblast at a glance
Autor: | Nina Noskovičová, Dong Ok Son, Boris Hinz, Monika Lodyga, Ronen Schuster, Henna Karvonen, Pardis Pakshir, Amanda Goodwin |
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Rok vydání: | 2020 |
Předmět: |
Cell type
Cell Biology Extracellular matrix 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Animals Myofibroblasts 030304 developmental biology 0303 health sciences Wound Healing Granulation tissue Cell Differentiation Cell Biology Fibroblasts medicine.disease Extracellular Matrix Rats medicine.anatomical_structure 030220 oncology & carcinogenesis Signal transduction Wound healing Myofibroblast Neuroscience |
Zdroj: | Journal of cell science. 133(13) |
ISSN: | 1477-9137 |
Popis: | In 1971, Gabbiani and co-workers discovered and characterized the “modification of fibroblasts into cells which are capable of an active spasm” (contraction) in rat wound granulation tissue and, accordingly, named these cells ‘myofibroblasts’. Now, myofibroblasts are not only recognized for their physiological role in tissue repair but also as cells that are key in promoting the development of fibrosis in all organs. In this Cell Science at a Glance and the accompanying poster, we provide an overview of the current understanding of central aspects of myofibroblast biology, such as their definition, activation from different precursors, the involved signaling pathways and most widely used models to study their function. Myofibroblasts will be placed into context with their extracellular matrix and with other cell types communicating in the fibrotic environment. Furthermore, the challenges and strategies to target myofibroblasts in anti-fibrotic therapies are summarized to emphasize their crucial role in disease progression. |
Databáze: | OpenAIRE |
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