Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study
| Autor: | María José Sánchez, José Antonio Baeyens-Fernández, Rosario Del Moral, Emilio Sánchez-Cantalejo Ramírez, Elena Molina-Portillo, Marina Pollán, Lorenzo Arribas-Mir, Miguel Rodríguez-Barranco |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), European Regional Development Fund (ERDF/FEDER), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Stage
Adult Cancer Research Registry Survival Population Breast Neoplasms Population-based lcsh:RC254-282 Cohort Studies 03 medical and health sciences 0302 clinical medicine Breast cancer Surgical oncology Survival rates Genetics Trend Medicine Humans 030212 general & internal medicine Breast Registries Stage (cooking) Mortality education Cancer Aged Aged 80 and over education.field_of_study business.industry Incidence (epidemiology) Mortality rate Incidence Cáncer Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis Cancer registry Oncology Spain 030220 oncology & carcinogenesis Female business Demography Research Article |
| Zdroj: | BMC Cancer Repisalud Instituto de Salud Carlos III (ISCIII) Digibug. Repositorio Institucional de la Universidad de Granada instname BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018) |
| ISSN: | 1471-2407 |
| Popis: | The incidence of breast cancer has increased since the 1970s. Despite favorable trends in prognosis, the role of changes in clinical practice and the introduction of screening remain controversial. We examined breast cancer trends to shed light on their determinants Overall, age-adjusted (European Standard Population) incidence rates increased from 48.0 cases × 100,000 women in 1985–1989 to 83.4 in 2008–2012, with an annual percentage change (APC) of 2.5% (95%CI, 2.1–2.9) for 1985–2012. The greatest increase was in women younger than 40 years (APC 3.5, 95%CI, 2.4–4.8). For 2000–2012 the incidence trend increased only for stage I tumors (APC 3.8, 95%CI, 1.9–5.8). Overall age-adjusted breast cancer mortality decreased (APC − 1, 95%CI, − 1.4 – − 0.5), as did mortality in the 50–69 year age group (APC − 1.3, 95%CI, − 2.2 – − 0.4). Age-standardized net survival increased from 67.5% at 5 years in 1985–1989 to 83.7% in 2010–2012. All age groups younger than 70 years showed a similar evolution. Five-year net survival rates were 96.6% for patients with tumors diagnosed in stage I, 88.2% for stage II, 62.5% for stage III and 23.3% for stage IV. Breast cancer incidence is increasing – a reflection of the evolution of risk factors and increasing diagnostic pressure. After screening was introduced, the incidence of stage I tumors increased, with no decrease in the incidence of more advanced stages. Reductions were seen for overall mortality and mortality in the 50–69 year age group, but no changes were found after screening implementation. Survival trends have evolved favorably except for the 70–84 year age group and for metastatic tumors. This study was supported by a grant from the Acción Estratégica en Salud plan for the High Resolution Project on Prognosis and Care of Cancer Patients (No. AC14/00036) awarded by the Spanish Ministry of Economy and Competitiveness and co-funded by the European Regional Development Fund (ERDF). |
| Databáze: | OpenAIRE |
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