Clinico-pathological characteristics of p63 expression in B-cell lymphoma
| Autor: | Masaru Ide, Naoko Sueoka, Noriko Funai, Noriyasu Fukushima, Rika Tomimasu, Toshimi Satoh, Nobuo Kuwahara, Akemi Sato, Osamu Tokunaga, Naoko Tsuneyoshi, Takashi Hisatomi, Masayuki Sano, Eisaburo Sueoka |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Lymphoma B-Cell Biology immune system diseases hemic and lymphatic diseases Gene expression medicine Humans RNA Messenger B-cell lymphoma Pathological Gene Aged Aged 80 and over integumentary system Tumor Suppressor Proteins Cancer Germinal center General Medicine Middle Aged Prognosis medicine.disease Lymphoma DNA-Binding Proteins Alternative Splicing stomatognathic diseases Oncology Trans-Activators Immunohistochemistry Female sense organs Transcription Factors |
| Zdroj: | Cancer Science. 97:1050-1055 |
| ISSN: | 1349-7006 1347-9032 |
| DOI: | 10.1111/j.1349-7006.2006.00284.x |
| Popis: | A member of the family of p53-related genes, p63 plays a role in regulating epithelial proliferation and differentiation programs, but the pathological and clinical meaning of p63 in B-cell lymphoma has not been elucidated. We investigated the expression pattern of p63 in B-cell malignancies, and evaluated the correlation between the expression of p63 and other germinal center markers. Ninety-eight B-cell lymphomas (28 FCL, 5 MCL, and 65 DLBCL) were analyzed by immunohistochemical examination for p63, bcl-6, CD10 and MUM-1 proteins, and for rearrangement of bcl-2/IgH. Expression of p63 was observed in the nuclei of tumor cells obtained from 15 of 28 (54%) FCL, 22 of 65 (34%) DLBCL, but none of 5 MCL. In DLBCL, the expression of p63 and bcl-6 showed a significant correlation (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text