Peritoneal cancer treatment
| Autor: | Akiyoshi Mizumoto, Yan Li, Haruaki Ishibashi, Kazuyoshi Takeshita, Gorou Tsukiyama, Nobuyuki Takao, Yan Liu, Yutaka Yonemura, Emel Canbay, Masamitsu Hirano, Masahiro Miura, Shouzou Sako, Yoshio Endou, Masumi Ichinose |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Neoplasm Residual medicine.medical_treatment Peritonectomy Internal medicine Humans Combined Modality Therapy Medicine Peritoneal Lavage Pharmacology (medical) Stage (cooking) Laparoscopy Peritoneal Neoplasms Neoadjuvant therapy Pharmacology Chemotherapy medicine.diagnostic_test business.industry fungi Cancer Multimodal therapy Hyperthermia Induced General Medicine medicine.disease Neoadjuvant Therapy Surgery business |
| Zdroj: | Expert Opinion on Pharmacotherapy. 15:623-636 |
| ISSN: | 1744-7666 1465-6566 |
| Popis: | In the past, peritoneal surface malignancy (PSM) was considered as a final stage of cancer, and patients were offered the best supportive care. Recently, a new therapeutic alternative approach based on the combination of surgery with chemotherapy was developed. In this curative intent, the macroscopic disease was treated with cytoreductive surgery (CRS) combined with perioperative chemotherapy, including neoadjuvant chemotherapy, hyperthermic intraoperative intraperitoneal chemotherapy, extensive intraoperative peritoneal lavage and early postoperative intraperitoneal chemotherapyThis article reviews the mechanisms of the formation of PSM, quantitative estimation of PSM and residual disease, multimodal treatment, value of laparoscopy, prognostic factors and patients' selection for the multimodal therapy.Recent studies show that CRS plus intraperitoneal chemotherapy applications confer prolonged survival in patients with PSM from colorectal, gastric, ovarian, appendiceal mucinous carcinoma and diffuse malignant peritoneal mesothelioma. The comprehensive treatment is now justified as state-of-the-art for patients with peritoneal metastasis. |
| Databáze: | OpenAIRE |
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