The prospective association between psychological distress and disease activity in rheumatoid arthritis: a multilevel regression analysis
| Autor: | Suzanne M M Verstappen, Henriët van Middendorp, C.L. Overman, Johannes W. J. Bijlsma, Ercolie R. Bossema, Johannes W G Jacobs, Marcia Bulder, Rinie Geenen, Leoniek Wijngaards-de Meij |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Exacerbation Immunology Blood Sedimentation Anxiety General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Young Adult Rheumatology Rheumatoid Factor Internal medicine medicine Humans Immunology and Allergy Rheumatoid factor Risk factor Association (psychology) Aged Aged 80 and over Psychiatric Status Rating Scales medicine.diagnostic_test Depression business.industry Middle Aged medicine.disease Connective tissue disease Rheumatoid arthritis Erythrocyte sedimentation rate Disease Progression Physical therapy Female medicine.symptom Epidemiologic Methods business Stress Psychological |
| Zdroj: | Annals of the Rheumatic Diseases. 71:192-197 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | Background Cross-sectional associations suggest a mutual impact of disease activity and psychological distress in rheumatoid arthritis (RA), but a prospective association has not been established. Objective To examine concurrent and prospective associations between psychological distress and disease activity. Methods Patients with RA (N=545, disease duration ≤1 year, age 18–83 years, 69% female, 64% rheumatoid factor (RF) positive) were monitored for 5 years. The Thompson joint score and erythrocyte sedimentation rate were assessed every 6 months. Depressed mood and anxiety were measured every 12 months. Multilevel regression analysis was used. RF positivity, age and female sex were included as covariates. Results Concurrent levels of psychological distress and disease activity were positively associated (p≤0.04). Prospectively, depressed mood was associated with disease activity levels 6 months later (p≤0.04). The Thompson joint score was associated with psychological distress levels 6 months later (p≤0.03) and also with an increase in depressed mood over the subsequent 6 months (p=0.02). No other significant prospective associations were found (p≥0.07). Conclusions Psychological distress and disease activity are positively associated when measured at the same time as well as when measured 6 months apart. While some support was found for the idea that a higher level of disease activity is a risk factor for an increase in psychological distress, the results do not support the notion that psychological distress is a risk factor for future exacerbation of disease activity. |
| Databáze: | OpenAIRE |
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