Vitamin D and Bone Mineral Density in Ambulatory Women Living in Buenos Aires, Argentina
| Autor: | J. R. Zanchetta, E. E. Fradinger |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
musculoskeletal diseases Aging medicine.medical_specialty Bone disease Endocrinology Diabetes and Metabolism Osteoporosis Parathyroid hormone vitamin D deficiency Body Mass Index Bone Density Internal medicine Vitamin D and neurology Humans Medicine Aged Calcifediol Retrospective Studies Femoral neck Aged 80 and over Bone mineral Lumbar Vertebrae Femur Neck business.industry Middle Aged musculoskeletal system medicine.disease Postmenopause medicine.anatomical_structure Endocrinology Parathyroid Hormone Regression Analysis Female business Body mass index |
| Zdroj: | Osteoporosis International. 12:24-27 |
| ISSN: | 1433-2965 0937-941X |
| Popis: | The aim of this study was to determine possible associations between bone mineral density (BMD), 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (PTH). In a retrospective study we examined the case notes of free-living postmenopausal women living in our city (34 degrees S). We also report a low prevalence of vitamin D deficiency (25(OH)D25 nmol/1, 5.6%) and of secondary hyperparathyroidism (intact PTH65 pg/ml, 7.5%). Age was correlated with BMD at the lumbar spine (r = -0.25, p = 0.00038) and femoral neck (r = -0.252, p = 0.0003). Body mass index (BMI) was correlated with BMD at the femoral neck (r = 0.177, p = 0.021) but not at the lumbar spine. 25(OH)D was positively correlated with BMD at the femoral neck (r = 0.149, p = 0.036) but not at the lumbar spine. PTH was positively correlated with age (r = 0.279, p = 0.012) and negatively correlated with 25(OH)D (r = -0.322, p = 0.0036). PTH was also negatively correlated with BMD at the lumbar spine (r = -0.258, p = 0.02) and the femoral neck (r = -0.282, p = 0.011). Forward stepwise multiple regression showed that BMI, age and 25(OH)D made significant contributions to BMD at the femoral neck. PTH also showed a significant contribution to BMD at both sites. In conclusion, weak correlations found between PTH and 25(OH)D and BMD suggest these biochemical variables, among other factors, contribute to lumbar spine and femoral neck BMD. |
| Databáze: | OpenAIRE |
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