Hepatocellular carcinoma is leading in cancer-related disease burden among hospitalized baby boomers
| Autor: | George Cholankeril, Paris Charilaou, Vijay S. Are, Eric R. Yoo, Aijaz Ahmed, Capecomorin S. Pitchumoni, Chiranjeevi Gadiparthi, Donghee Kim |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Baby boomers Specialties of internal medicine Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Pancreatic cancer medicine Humans HCC Mortality Disease burden Aged Retrospective Studies Inpatients Hepatology business.industry Incidence Liver Neoplasms Cancer Retrospective cohort study General Medicine Hepatitis C Chronic Middle Aged medicine.disease Primary cancer digestive system diseases United States Hospitalization Survival Rate RC581-951 030220 oncology & carcinogenesis Hepatocellular carcinoma Inpatient incidence Cohort HCV Disease Progression 030211 gastroenterology & hepatology Female Morbidity business |
| Zdroj: | Annals of Hepatology, Vol 18, Iss 5, Pp 679-684 (2019) |
| ISSN: | 1665-2681 |
| Popis: | Introduction and Objectives Three fourths of chronic hepatitis C virus (HCV) infected adult patients in the United States (US) are born between 1945 and 1965, also known as baby boomers (BB). Prevalence of hepatocellular carcinoma (HCC) is raising in BB due to their advancing age and prolonged HCV infection. We evaluated inpatient hospitalization and mortality in BB associated with HCC. Materials and methods It is a retrospective cohort study utilizing the Healthcare Utilization Project-National Inpatient Sample (HCUP-NIS) database. From 2003 to 2012, top five primary cancer related hospitalization and mortality among BB were studied. Results Among 48,733 hospitalizations related to HCC in HCUP-NIS database from 2003 to 2012, BB accounted for 49.6% (24,210) whereas non-BB 50.4% (24,523). Within BB cohort, the top five cancers with the highest proportion of hospitalizations were HCC (46%), prostate (43%), kidney (41%), pancreas (33%), and bladder (21%). From 2003 to 2012, the proportion of HCC related hospitalizations represented by BB almost doubled (33.5 to 57.8%) whereas there was one-third reduction (66.4 to 42.1%) among non-BB. Similarly, HCC-related inpatient mortality in BB decreased by 28% (6.1 to 2.7 per 100,000 hospitalization) but it remained unchanged in non-BB (11.1 to 10.6). HCC accounted for 2nd highest mortality (4960 total deaths) among hospitalized BB behind pancreatic cancer. HCC related to HCV was disproportionately higher in BB compared to non-BB (50.6% vs. 19%; P Conclusion HCC ranks number one among the top five cancers with highest proportion of inpatient burden. Future studies should focus on understanding the underlying reasons for this ominous trend. |
| Databáze: | OpenAIRE |
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