Blood rheology in the endotoxin-administered rabbits
| Autor: | Nobuko Tsushima, Kozaburo Hayashi, Keiichi Takamizawa, Tadashi Kato |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Blood viscosity Blood Pressure Femoral artery Emergency Nursing Hematocrit medicine.artery Internal medicine Animals Medicine Erythrocyte deformability Saline Lagomorpha biology medicine.diagnostic_test business.industry Viscometer Shock Blood Viscosity biology.organism_classification Surgery Endotoxins Red blood cell medicine.anatomical_structure Endocrinology Blood Circulation Emergency Medicine Rabbits Cardiology and Cardiovascular Medicine business |
| Zdroj: | Resuscitation. 23:137-144 |
| ISSN: | 0300-9572 |
| DOI: | 10.1016/0300-9572(92)90198-l |
| Popis: | The effects of endotoxin on blood rheology were studied in rabbits. Non-treated six rabbits (Group A) were used to obtain control data. Thirteen rabbits who were administered 0.1 mg of endotoxin three times at intervals of 3 days were divided into two groups; seven rabbits (Group B) were injected with 1 ml saline solution as the vehicle for endotoxin at 7 days after the final administration of endotoxin, while the remaining six rabbits (Group C) were administered endotoxin at 0.2 mg/kg on the same day. Blood was sampled from the femoral artery 120 min after the final treatment. Blood viscosity was measured at a shear rate of 150 s −1 at 37°C using a cone-plate viscometer. The passage time for a 5% red blood cell suspension and that for plasma were determined by filtration; the former represents erythrocyte deformability while the latter is related to plasma fluidity. The hematocrit, whole blood viscosity and erythrocyte deformability did not show significant differences among these three groups. The ratio of hematocrit to whole blood viscosity is considered to be an index of oxygen delivery from the hemorheologic point. This index did not show significant difference either. A good correlation was observed between whole blood viscosity and hematocrit in Group A, but not in the endotoxin-treated groups. The plasma fluidity was lower in Groups B and C than in Group A. These data indicate that plasma fluidity and the hematocrit-viscosity relationship are affected in endotoxin-treated rabbits, although blood viscosity, erythrocyte deformability and oxygen delivery hardly changed. |
| Databáze: | OpenAIRE |
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