The Changes of Cholesterol Profile at the Different Insulin Resistance Range in the Czech Republic
| Autor: | Jan Šlégr, Vladimír Kron, Filip Studnička, Pavel Smetana, Damián Bušovský, Karel Martiník, Miroslav Verner, Dagmar Horáková |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Medicine (General) insulin HDL lipoprotein LDL glucose HOMA IR medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Carbohydrate metabolism Article Fasting glucose 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance R5-920 Internal medicine medicine Humans Triglycerides Czech Republic Cholesterol business.industry Insulin Cholesterol HDL nutritional and metabolic diseases Lipid metabolism General Medicine medicine.disease Endocrinology chemistry Homeostatic model assessment lipids (amino acids peptides and proteins) Insulin Resistance business Lipoprotein |
| Zdroj: | Medicina; Volume 57; Issue 3; Pages: 249 Medicina Medicina, Vol 57, Iss 249, p 249 (2021) Volume 57 Issue 3 |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina57030249 |
| Popis: | Background and Objectives: The mechanism of the relationship between glycemia and lipid metabolism has not been completely clarified, and slight differences may be found between authors and the kinds of evaluated parameters. Therefore, this study focused on possible changes of lipoprotein profile with regards to HOMA IR (Homeostatic Model Assessment for Insulin Resistance) cut-off 3.63, considered a signal of glucose metabolism alterations. Materials and Methods: The metabolic profiles of 3051 individuals were divided by HOMA IR values into two groups below cut-off 3.63, including (n = 2627) and above cut-off (n = 424). Patients taking medication or supplements to affect lipid, insulin, or glucose metabolism were excluded. Fasting glucose levels, insulin, and lipoproteins (total, HDL—high density and LDL—low density lipoprotein cholesterol) were compared between the groups with different HOMA IR. After analysis of data distribution, F-test and t-test were provided to compare variances and mean values. Results: The evaluation shows that the kind of cholesterol is crucial for a possible relationship with glucose metabolism and consequently confirms the changes of lipoproteins (HDL and LDL) by HOMA IR cut-off 3.63. Conclusions: The results of patients divided by HOMA IR cut-off 3.63 also suggest possible changes in the regulation of glucose metabolism and lipoprotein concentrations (HDL and LDL). |
| Databáze: | OpenAIRE |
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