Characteristics of Cardiac Injury in Critically Ill Patients With Coronavirus Disease 2019
| Autor: | Jean-Paul Mira, Mathieu Jozwiak, Emile Ferrari, Matthieu Buscot, Hervé Hyvernat, Pierre Dupland, Denis Doyen, Matthieu Jamme, Etienne Fourrier, Lucas Morand, Clément Saccheri, Jean Dellamonica, Gilles Bernardin, Alain Cariou |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
Pulmonary and Respiratory Medicine medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Critical Care and Intensive Care Medicine Pericardial effusion 03 medical and health sciences 0302 clinical medicine Internal medicine Intensive care Medicine cardiovascular diseases 030212 general & internal medicine biology business.industry Critically ill Incidence (epidemiology) medicine.disease Troponin Icu admission 030228 respiratory system cardiovascular system biology.protein Cardiology business Cardiology and Cardiovascular Medicine |
| Zdroj: | Chest |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2020.10.056 |
| Popis: | Background Cardiac injury has been reported in up to 30% of COVID-19 patients. However, cardiac injury was mainly defined by troponin elevation without description of associated structural abnormalities and its time course has never been studied. Research question What are the electrocardiographic and echocardiographic abnormalities as well as their time course in critically ill COVID-19 patients? Study design and methods The cardiac function of 43 consecutive COVID-19 patients admitted in two intensive care units (ICU) was prospectively and repeatedly assessed combining electrocardiographic, cardiac biomarkers and transthoracic echocardiographic analyses from ICU admission (D0) to ICU discharge or death or to a maximum follow-up of 14 days. Cardiac injury was defined by troponin elevation and newly diagnosed electrocardiographic and/or echocardiographic abnormalities. Results At D0, 49% of patients had a cardiac injury and 70% of patients experienced cardiac injury within the first 14 days of ICU stay, with a median time of occurrence of 3[0-7] days. The most frequent abnormalities were electrocardiographic and/or echocardiographic signs of left ventricular (LV) abnormalities (87% of patients with cardiac injury), right ventricular (RV) systolic dysfunction (47%), pericardial effusion (43%), new-onset atrial arrhythmias (33%), LV relaxation impairment (33%) and LV systolic dysfunction (13%). Between D0 and D14, the incidence of pericardial effusion and of new-onset atrial arrhythmias increased, the incidence of electrocardiographic and/or echocardiographic signs of LV abnormalities as well as the incidence of LV relaxation impairment remained stable, whereas the incidence of RV and LV systolic dysfunction decreased. Interpretation Cardiac injury is common and early in critically ill COVID-19 patients. Electrocardiographic and/or echocardiographic signs of LV abnormalities were the most frequent abnormalities and patients with cardiac injury experienced more RV than LV systolic dysfunction. |
| Databáze: | OpenAIRE |
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