GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese
| Autor: | Lingli Sun, Xinfeng Liu, Yonggang Hao, Huan Cai, Zhizhong Zhang, Zongliang Xu, Zusen Ye, Hao Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Neurology Genes Recessive Genome-wide association study Single-nucleotide polymorphism Comorbidity 030204 cardiovascular system & hematology Logistic regression Polymorphism Single Nucleotide Severity of Illness Index 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Asian People Modified Rankin Scale Internal medicine Genotype Ethnicity Humans Medicine Single-Blind Method Prospective Studies Aged Genes Dominant Metabolic Syndrome Models Genetic biology business.industry Smoking Haplotype C-reactive protein Middle Aged Atherosclerosis Stroke C-Reactive Protein Treatment Outcome Haplotypes biology.protein Molecular Medicine Female business 030217 neurology & neurosurgery Follow-Up Studies Genome-Wide Association Study |
| Zdroj: | NeuroMolecular Medicine. 20:225-232 |
| ISSN: | 1559-1174 1535-1084 |
| DOI: | 10.1007/s12017-018-8485-y |
| Popis: | Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with first-ever LAA IS were prospectively enrolled in Nanjing Stroke Registry Program between August 2013 and October 2015. Five single-nucleotide polymorphisms (SNPs) (rs876537, rs2794520, rs3093059, rs7553007 and rs11265260) in CRP gene related to CRP levels in Asian by genome-wide association study were genotyped. The functional outcome at 3 months after the index stroke was assessed by the modified Rankin scale. Associations between genotypes and functional outcome of LAA IS were analyzed with logistic regression model. A total of 690 eligible patients (507 males) were evaluated. SNPs rs11265260 (multivariate-adjusted, p = 0.022), rs2794520 (multivariate-adjusted, p = 0.036) and rs3093059 (multivariate-adjusted, p = 0.027) were significantly associated with elevated CRP in acute IS. Two SNPs, rs3093059 (dominant model: adjusted OR 2.49; 95% CI 1.55-4.00; recessive model: adjusted OR 3.67; 95% CI 1.22-11.03) and rs11265260 (dominant model: adjusted OR 2.51; 95% CI 1.56-4.02; recessive model: adjusted OR 4.70; 95% CI 1.63-13.56) independently predicted 3-month poor outcome of first-ever LAA IS, after adjusting for covariates. In addition, haplotype analysis indicated that haplotype GCTGC (adjusted OR 1.76; 95% CI 1.05-2.95; p = 0.031) increased the poor outcome risk. SNPs rs3093059 and rs11265260 in CRP gene may influence the 3-month functional outcome of first-ever LAA IS in Han Chinese. |
| Databáze: | OpenAIRE |
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