Facile amidinations of 2-aminophenylboronic acid promoted by boronate ester formation
| Autor: | Peter Conrad Healy, Milton J. Kiefel, Taylor A. Garget, Brighid Beatrice Pappin, Todd Ashley Houston, Michela I. Simone |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
Aminophenylboronic acid 010405 organic chemistry fungi Organic Chemistry food and beverages chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Amidine chemistry.chemical_compound chemistry Amine gas treating Physical and Theoretical Chemistry Boron |
| Zdroj: | Organic & Biomolecular Chemistry. 17:803-806 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | Amidine synthesis by amine addition to nitriles normally requires high temperatures or harsh catalysts. Here, we report that boronate esters can facilitate amidination of proximal amines with moderate heating. With amidines present in a number of drugs and the synthetic handle provided by the boron, this chemistry should find useful applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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