Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchange
| Autor: | Lidon Rm, Marisol Ruiz-Meana, David Garcia-Dorado, José A. Barrabés, H. M. Piper, Yolanda Puigfel, Julia Solares, Jordi Soler-Soler, Blanco J, Miguel A. González |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Sodium-Hydrogen Exchangers Physiology Swine Ischemia Diastole Myocardial Infarction Myocardial Reperfusion Injury Guanidines Reperfusion therapy Physiology (medical) Internal medicine Occlusion Medicine Animals Sulfones biology business.industry Myocardium Arrhythmias Cardiac Ischemic Contracture medicine.disease Myocardial Contraction Enzyme inhibitor Coronary occlusion Anesthesia biology.protein Cardiology Contracture medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular research. 35(1) |
| ISSN: | 0008-6363 |
| Popis: | Objective: To determine the effect of Na+–H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. Methods: Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemic rigor (reduction in passive segment length change) and hypercontracture (reduction in end-diastolic length). Results: Pretreatment with the new, highly selective Na+–H+ exchange inhibitor HOE642 before occlusion reduced ischemic rigor ( P |
| Databáze: | OpenAIRE |
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