Platelet function and thrombin activity in patients with recent cerebral transient ischemic attacks
| Autor: | Maria Cristina Giusti, M P Seveso, Massimo Franceschi, Aurelio M. Vicari, A Macagni, Stefania Medaglini, Roberta Luoni |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Platelet Aggregation Platelet Function Tests Fibrinopeptide A chemistry.chemical_compound Instrumental evaluation Internal medicine medicine Humans Platelet In patient Advanced and Specialized Nursing medicine.diagnostic_test business.industry Thrombin Middle Aged beta-Thromboglobulin Surgery Thromboxane B2 Doppler sonography chemistry Ischemic Attack Transient Thrombin activity Cardiology Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Cerebral angiography |
| Zdroj: | Stroke. 18:892-895 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.18.5.892 |
| Popis: | Platelet function and thrombin activity were investigated in 12 hospitalized patients (7 men and 5 women, mean age 53 years) who had had transient cerebral ischemic attacks in the previous 2-12 weeks. Each patient was given an extensive clinical and instrumental evaluation, including Doppler sonography of the cervical and lower limb vessels, cerebral angiography, and head computed tomography scan, after which relevant atherosclerotic disease was excluded. The controls consisted of 12 subjects hospitalized for nonvascular neurologic problems and matched for age, sex, and risk factors to the transient ischemic attack patients. Collagen-induced platelet thromboxane B2 production, plasma beta-thromboglobulin, and fibrinopeptide A were significantly higher in the patients than the controls. Platelet aggregability by collagen was the same in the 2 groups. Platelet hyperfunction and enhanced thrombin activity are present in patients some weeks after the acute episode, suggesting that the hemostatic system has a primary pathogenetic role. |
| Databáze: | OpenAIRE |
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