SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite
| Autor: | Marco Poeta, Valentina Cioffi, Vittoria Buccigrossi, Francesco Corcione, Roberto Peltrini, Angela Amoresano, Fabio Magurano, Maurizio Viscardi, Giovanna Fusco, Antonietta Tarallo, Carla Damiano, Andrea Lo Vecchio, Eugenia Bruzzese, Alfredo Guarino |
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| Přispěvatelé: | Poeta, Marco, Cioffi, Valentina, Buccigrossi, Vittoria, Corcione, Francesco, Peltrini, Roberto, Amoresano, Angela, Magurano, Fabio, Viscardi, Maurizio, Fusco, Giovanna, Tarallo, Antonietta, Damiano, Carla, Lo Vecchio, Andrea, Bruzzese, Eugenia, Guarino, Alfredo |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Heliyon. 8(8) |
| ISSN: | 2405-8440 |
| Popis: | The pathophysiology of SARS-CoV-2-associated diarrhea is unknown. Using an experimental model validated for rotavirus-induced diarrhea, we investigated the effects of SARS-CoV-2 on transepithelial ion fluxes and epithelial integrity of human intestinal cells. The effect of the antidiarrheal agent diosmectite on secretion was also evaluated following its inclusion in COVID-19 management protocols.We evaluated electrical parameters (intensity of short-circuit current [hiSARS-CoV-2 induced an increase inSARS-CoV-2 induces calcium-dependent chloride secretion and oxidative stress without damaging intestinal epithelial structure. The effects are largely induced by the spike protein and are significantly reduced by diosmectite. SARS-CoV-2 should be added to the list of human enteric pathogens. |
| Databáze: | OpenAIRE |
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