Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine
| Autor: | Alberto Posabella, Andrea B. Alber, Hendrik J. Undeutsch, Raoul A. Droeser, Anthony N. Hollenberg, Laertis Ikonomou, Darrell N. Kotton |
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| Rok vydání: | 2021 |
| Předmět: |
Pluripotent Stem Cells
endocrine system Endocrinology Diabetes and Metabolism regenerative medicine Review Regenerative medicine Diseases of the endocrine glands. Clinical endocrinology Endocrinology Directed differentiation medicine Animals Humans Progenitor cell Induced pluripotent stem cell business.industry directed differentiation Thyroid congenital hypothyroidism Cell Differentiation RC648-665 thyroid follicular cells medicine.disease Thyroid Diseases Congenital hypothyroidism Transplantation medicine.anatomical_structure Thyroid Epithelial Cells Cancer research Stem cell business Stem Cell Transplantation |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2021.666565 |
| Popis: | Stem cell-based therapies to reconstitute in vivo organ function hold great promise for future clinical applications to a variety of diseases. Hypothyroidism resulting from congenital lack of functional thyrocytes, surgical tissue removal, or gland ablation, represents a particularly attractive endocrine disease target that may be conceivably cured by transplantation of long-lived functional thyroid progenitors or mature follicular epithelial cells, provided a source of autologous cells can be generated and a variety of technical and biological challenges can be surmounted. Here we review the emerging literature indicating that thyroid follicular epithelial cells can now be engineered in vitro from the pluripotent stem cells (PSCs) of mice, normal humans, or patients with congenital hypothyroidism. We review the in vivo embryonic development of the thyroid gland and explain how emerging discoveries in developmental biology have been utilized as a roadmap for driving PSCs, which resemble cells of the early embryo, into mature functional thyroid follicles in vitro. Finally, we discuss the bioengineering, biological, and clinical hurdles that now need to be addressed if the goals of life-long cure of hypothyroidism through cell- and/or gene-based therapies are to be attained. |
| Databáze: | OpenAIRE |
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