High-fat diet-induced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop

Autor:	Christoph van Riesen, Joachim Spranger, Jennifer Altschüler, Lukas Maurer, Andrea A. Kühn, Jens K. Haumesser, Hui Tang
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	0301 basic medicine medicine.medical_specialty lcsh:Medicine Nucleus accumbens Biology Diet High-Fat 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten Neural circuits Energy homeostasis Basal Ganglia Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Basal ganglia Neural Pathways medicine Animals Humans Beta Rhythm Obesity Beta (finance) lcsh:Science Membrane potential Cerebral Cortex Multidisciplinary lcsh:R Motor Cortex Extremities medicine.disease Cortex (botany) Rats Electrophysiology 030104 developmental biology Endocrinology lcsh:Q Insulin Resistance Energy Metabolism 030217 neurology & neurosurgery
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-017-15872-x
Popis:	The concept of brain circuit disorders has been proposed for a variety of neuropsychiatric diseases, characterized by pathological disturbances of neuronal networks including changes in oscillatory signaling of re-entrant cortico-subcortical loops in the basal ganglia system. Parts of this circuitry play a pivotal role in energy homeostasis. We therefore investigated whether high-fat diet (HFD) induced obesity is associated with changes in oscillatory signaling in the limbic cortico-basal ganglia loop. We performed multi-site in-vivo electrophysiological recordings of local field potentials within this network under urethane anesthesia in adult rats after 4 weeks of HFD feeding compared to age-matched controls. Recordings were performed at baseline and during systemic glucose challenge. Our analysis demonstrates increased oscillatory beta power in the nucleus accumbens (NAC) associated with decreased beta coherence between cortex and NAC in animals fed a HFD. Spontaneous beta oscillatory power strongly correlated with endocrine markers of obesity. The glucose challenge increased beta oscillations in control animals but not in animals receiving the HFD. Furthermore direct intracerebroventricular insulin injection increased beta oscillations in the NAC. The present study provides evidence for aberrant oscillatory signaling in the limbic cortico-basal ganglia loop that might contribute to the dysfunctional information processing in obesity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8502a259dec8f2d2ba754c0c61538738 http://link.springer.com/article/10.1038/s41598-017-15872-x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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