Altered expression of syndecan-1 in prostate cancer
| Autor: | Markku Jalkanen, Kalle Alanen, Johanna Kiviniemi, Markku Salmivirta, Marja-Terttu Matikainen, Iina Kujala, Markku Kallajoki |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Microbiology (medical) PCA3 Pathology medicine.medical_specialty Syndecans animal structures Biology Pathology and Forensic Medicine Syndecan 1 Rats Sprague-Dawley Mice Prostate cancer Prostate medicine Animals Humans Immunology and Allergy Aged Aged 80 and over Membrane Glycoproteins Cell growth Antibodies Monoclonal Prostatic Neoplasms Cancer General Medicine Middle Aged medicine.disease Immunohistochemistry Rats carbohydrates (lipids) medicine.anatomical_structure embryonic structures Cancer cell NIH 3T3 Cells Proteoglycans Syndecan-1 |
| Zdroj: | APMIS. 112:89-97 |
| ISSN: | 1600-0463 0903-4641 |
| DOI: | 10.1111/j.1600-0463.2004.apm1120202.x |
| Popis: | Syndecan-1 is a cell surface heparan sulfate proteoglycan expressed by epithelial cells. It interacts with growth factors, matrix components, and other extracellular proteins, and is thought to be involved in processes such as cell growth, differentiation and adhesion. The expression of syndecan-1 appears generally downregulated in human carcinomas and in experimental cancer models, whereas transfectional expression of syndecan-1 in cultured cancer cells has been shown to inhibit their growth and other aspects of malignant behavior. These findings suggest that analysis of syndecan-1 expression might be of prognostic value in cancer diagnosis, and studies on some carcinomas indeed point to an inverse correlation between syndecan-1 expression and cancer prognosis. So far, little information has been available on the expression of syndecan-1 in human prostate and prostate disease. We have generated and characterized novel antibodies against syndecan-1 and applied them to immunohistochemical staining of specimens representing normal prostate as well as benign and malignant (n=23) prostate disease. The results indicate that syndecan-1 expression is altered but not uniformly absent in prostate cancer, which is in contrast to the expression of high-molecular-weight cytokeratins. The data initially suggest an inverse correlation between syndecan-1 expression and Gleason grade of the tumor, and warrant a larger study to assess the potential prognostic value of analysing syndecan-1 expression in prostate carcinoma. |
| Databáze: | OpenAIRE |
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