Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects
| Autor: | P. Rousset, Yves Boirie, Béatrice Morio, Pierre Gachon, Christophe Giraudet, Aude Zangarelli, Christelle Guillet |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Université d'Auvergne - Clermont-Ferrand I (UdA), Centre de Recherche en Nutrition Humaine, CHU Clermont-Ferrand |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism medicine.medical_treatment [SDV]Life Sciences [q-bio] Clinical Biochemistry 030209 endocrinology & metabolism Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology DEREGLEMENT PHYSIOLOGIQUE Leucine Internal medicine Hyperinsulinemia medicine Humans Insulin Amino Acids Pentanoic Acids Pancreatic hormone 030304 developmental biology Aged 2. Zero hunger chemistry.chemical_classification 0303 health sciences Biochemistry (medical) Osmolar Concentration Proteins Carbon Dioxide medicine.disease Amino acid Protein catabolism Glucose chemistry Basal (medicine) Exhalation Body Composition Hyperaminoacidemia |
| Zdroj: | 25. Congress of the European-Society-of-Parenteral-and-Enteral-Nutrition 25. Congress of the European-Society-of-Parenteral-and-Enteral-Nutrition, Sep 2003, Cannes, France. ⟨10.1210/jc.2003-031323⟩ Journal of Clinical Endocrinology and Metabolism Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2004, 89 (12), pp.6017-6024. ⟨10.1210/jc.2003-031323⟩ |
| ISSN: | 0021-972X 1945-7197 |
| Popis: | This study was presented in part at the 25th Congress of the European Society of Parenteral and Enteral Nutrition, September 2003, Cannes, France [Clin Nutr S1:14(052)].; International audience; Responses of whole body glucose disposal (GDR) and protein breakdown (PB) to physiological insulin levels are altered in nondiabetic elderly subjects. Amino acids enhance inhibition of PB by insulin in young subjects. We hypothesized that addition of amino acid to insulin may improve the defect in PB regulation by insulin in elderly people. Therefore, we investigated the effect of hyperinsulinemia combined to either euaminoacidemia (EuAA) or hyperaminoacidemia (HyperAA) on GDR and PB, using isotopic dilution of D-[6,6-2H2]glucose and L-[1-13C]leucine, in young (mean +/- SEM, 24.4 +/- 0.8 yr) and elderly (70.2 +/- 0.7 yr) subjects. GDR was lower in elderly than in young subjects in all situations (P < 0.05). Despite a greater inhibition with HyperAA, PB was less inhibited in elderly than in young subjects during both clamps (ratio between change over basal PB and change over basal insulinemia, -0.014 +/- 0.002 vs. -0.024 +/- 0.003 in EuAA and -0.022 +/- 0.002 vs. -0.036 +/- 0.003 micromol/ml.microU/kg fat-free mass.min in HyperAA; elderly vs. young, P < 0.05). In conclusion, in nondiabetic elderly subjects, PB is less inhibited by insulin with either basal or high amino acid concentrations. Addition of amino acid potentiates insulin-induced suppression of PB in both groups to the same extent, suggesting a specific dysregulation of PB by insulin with age. |
| Databáze: | OpenAIRE |
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