Eight Cases of Small Cell Neuroendocrine Carcinoma of the Head and Neck
| Autor: | Kenichi Ando, Takanori Wakaoka, Hisamitsu Hayashi, Mitsuhiro Aoki, Bunya Kuze, Masami Onishi, Hiromichi Shirato, Yatsuji Ito, Keisuke Mizuta, Shigeaki Tanahashi, Hirofumi Shibata, Takesumi Nishihori |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Nasal cavity medicine.medical_specialty Biopsy medicine.medical_treatment Small-cell carcinoma 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Carcinoma Small Cell 030223 otorhinolaryngology Survival rate Lymph node Aged Aged 80 and over business.industry Middle Aged medicine.disease Carcinoma Neuroendocrine Radiation therapy medicine.anatomical_structure Paranasal sinuses Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | Nippon Jibiinkoka Gakkai Kaiho. 120:202-208 |
| ISSN: | 1883-0854 0030-6622 |
| Popis: | Small cell neuroendocrine carcinoma of the head and neck is a rarely occurring poorly differentiated and high-grade malignant neoplasm characterized by highly active proliferation of neuroendocrine tumor cells. There are no established therapies for this disease. To clarify the clinical course and develop effective treatment(s) for the carcinoma, we reviewed the data of 8 patients of small cell neuroendocrine carcinoma of the head and neck treated by us between 2006 and 2014 at the Department of Otolaryngology, Gifu University School of Medicine and our affiliated hospitals. The patients consisted of 3 men and 5 women, ranging in age from 38 to 84 years old (mean : 60.9 years). The tumor arose from the nasal cavity or the paranasal sinuses in 3 cases, from the parotid grand in 2 cases, from the oropharynx in 2 cases, and from the hypopharynx in 1 case. The tumor that arose from the hypopharynx was a combined small-cell carcinoma with squamous cell carcinomas, and the one that arose from the oropharynx had already metastasized to the brain. Most of the patients were treated by chemotherapy and radiotherapy based on the treatment employed for small cell carcinoma of the lung. Only the patient in whom the tumor arose from a paranasal sinus was treated by surgery despite the definitive diagnosis of small cell carcinoma. We selected CPT-11 and a platinum agent for 4 patients, and VP-16 and a platinum agent for 3 patients as the first-line chemotherapy. Although two patients showed carcinoma-free survival, one died of recurrence of the regional lymph node metastases and five died of distant metastases despite the absence of locoregional recurrence. The 5-year survival rate was a dismal 25%, suggesting that we need to establish effective treatment(s) for the control of distant metastases in cases of the small cell neuroendocrine carcinoma of the head and neck. |
| Databáze: | OpenAIRE |
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