Safety and tolerability during build-up phase of a rush venom immunotherapy
| Autor: | Andrea Bauer, Kathleen Bernkopf, Henriette Rönsch, Petra Spornraft-Ragaller, Volker Neumeister |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Risk Pulmonary and Respiratory Medicine medicine.medical_specialty Multivariate analysis Adolescent Wasps Immunology Venom Logistic regression Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Sex Factors 0302 clinical medicine Internal medicine Hypersensitivity Animals Humans Immunology and Allergy Medicine Young adult Aged Venoms business.industry Maintenance dose Allergens Bees Middle Aged Venom immunotherapy 030228 respiratory system Tolerability Desensitization Immunologic Concomitant Female business |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 116:360-365 |
| ISSN: | 1081-1206 |
| DOI: | 10.1016/j.anai.2016.02.014 |
| Popis: | Background Safety and tolerability of venom immunotherapy (VIT) in patients with concomitant disease and comedications, especially β-blockers (BBs) and angiotensin-converting enzyme inhibitors (ACEIs), are under discussion. Objective To identify risk factors for the occurrence of systemic reactions (SRs) during the build-up phase of a 3-day rush VIT with focus on comorbidities and related comedications. Methods Data of 175 three-day rush VIT courses ( Vespula venom, n = 161; honeybee venom, n = 14) were analyzed. Starting with 0.02 μg of venom, the maintenance dose of 100 μg was reached in 15-dose increments within 3 days. Local reactions (LRs) and SRs were documented during the build-up phase. Comorbidities and related comedications were registered. Univariate, bivariate, and multivariate data analysis was performed. Results During the 3-day rush VIT, an LR was seen in 74 (42.3%) of 175, a large LR (>10-cm diameter) in 82 (46.9%) of 175, and SRs in 19 (10.9%) of 175 VIT courses. Multivariate logistic regression revealed that female sex ( P = .01), immunotherapy with honeybee venom ( P = .003), and accompanying ACEI medication ( P = .03) were independent predictors of the development of SRs during the build-up phase of VIT. Conclusion This study revealed that female sex, honeybee VIT, and ACEI use independent predictors for SRs. |
| Databáze: | OpenAIRE |
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