Differences in three-dimensional upper airway anatomy between Asian and European patients with obstructive sleep apnea
| Autor: | Zhifang Wang, Sigurdur Juliusson, Brendan T. Keenan, Bethany Staley, Richard Schwab, Thorarinn Gislason, Allan I. Pack, Bryndis Benedikstdottir, Jianjun Wang, Liyue Xu, Luqi Chi, A S Wiemken |
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| Rok vydání: | 2019 |
| Předmět: |
Male
China Polysomnography Iceland Asian People Tongue Physiology (medical) medicine Humans Craniofacial Orthodontics Sleep Apnea Obstructive medicine.diagnostic_test Soft palate business.industry Soft tissue Magnetic resonance imaging medicine.disease Obstructive sleep apnea medicine.anatomical_structure Maxilla Pharynx Neurology (clinical) Palate Soft Sleep Disordered Breathing business Airway |
| Zdroj: | Sleep |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/zsz273 |
| Popis: | Study Objectives This study evaluated differences in upper airway, soft tissues and craniofacial structures between Asians from China and Europeans from Iceland with OSA using three-dimensional magnetic resonance imaging (MRI). Methods Airway sizes, soft tissue volumes, and craniofacial dimensions were compared between Icelandic (N = 108) and Chinese (N = 57) patients with oxygen desaturation index (ODI) ≥ 10 events/h matched for age, gender, and ODI. Mixed effects models adjusting for height or BMI and residual differences in age and ODI were utilized. Results In our matched sample, compared to Icelandic OSA patients, Chinese patients had smaller BMI (p < 0.0001) and neck circumference (p = 0.011). In covariate adjusted analyses, Chinese showed smaller retropalatal airway size (p ≤ 0.002), and smaller combined soft tissues, tongue, fat pads, and pterygoid (all p ≤ 0.0001), but male Chinese demonstrated a larger soft palate volume (p ≤ 0.001). For craniofacial dimensions, Chinese demonstrated bigger ANB angle (p ≤ 0.0196), differently shaped mandibles, including shorter corpus length (p < 0.0001) but longer ramus length (p < 0.0001), and a wider (p < 0.0001) and shallower (p ≤ 0.0001) maxilla. Conclusions Compared to Icelandic patients of similar age, gender and ODI, Chinese patients had smaller retropalatal airway and combined soft tissue, but bigger soft palate volume (in males), and differently shaped mandible and maxilla with more bony restrictions. Results support an ethnic difference in upper airway anatomy related to OSA, which may inform targeted therapies. |
| Databáze: | OpenAIRE |
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