The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis
Autor: | Preetinder K. Aujla, Zamaneh Kassiri, Sayantan Jana, Michael Chute |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system Fibrillar collagen extracellular matrix Review heart 030204 cardiovascular system & hematology Extracellular matrix 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Extracellular Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics remodeling Basement membrane chemistry.chemical_classification Chemistry fibrosis Ischemic injury medicine.disease basement membrane Cell biology 030104 developmental biology medicine.anatomical_structure lcsh:RC666-701 proteoglycans Myocardial fibrosis Glycoprotein |
Zdroj: | Journal of Cardiovascular Development and Disease, Vol 6, Iss 4, p 35 (2019) Journal of Cardiovascular Development and Disease |
ISSN: | 2308-3425 |
Popis: | The extracellular matrix (ECM) provides structural support and a microenvironmentfor soluble extracellular molecules. ECM is comprised of numerous proteins which can be broadly classified as fibrillar (collagen types I and III) and non-fibrillar (basement membrane, proteoglycans, and glycoproteins). The basement membrane provides an interface between the cardiomyocytes and the fibrillar ECM, while proteoglycans sequester soluble growth factors and cytokines. Myocardial fibrosis was originally only linked to accumulation of fibrillar collagens, but is now recognized as the expansion of the ECM including the non-fibrillar ECM proteins. Myocardial fibrosis can be reparative to replace the lost myocardium (e.g., ischemic injury or myocardial infarction), or can be reactive resulting from pathological activity of fibroblasts (e.g., dilated or hypertrophic cardiomyopathy). Contribution of fibrillar collagens to fibrosis is well studied, but the role of the non-fibrillar ECM proteins has remained less explored. In this article, we provide an overview of the contribution of the non-fibrillar components of the extracellular space of the heart to highlight the potential significance of these molecules in fibrosis, with direct evidence for some, although not all of these molecules in their direct contribution to fibrosis. |
Databáze: | OpenAIRE |
Externí odkaz: |