Distribution of killer cell immunoglobulin-like receptor (KIR) genes in a large, multi-centre cohort of Chinese donors

Autor:	Zheng Zhongzheng, Du Keming, Peili Xiao, Ming Jiang, Ning-Juan Wang, Qin Sun, Dai-Yang Li, Qi Weng, He Qingqing, Liao Kuanzhen, Liping Wang, Min He, Jian Wang, Lin An
Rok vydání:	2021
Předmět:	0301 basic medicine China Heterozygote Aging Physiology Epidemiology Killer-cell immunoglobulin-like receptor Cell chemical and pharmacologic phenomena Biology Cohort Studies 03 medical and health sciences 0302 clinical medicine Gene Frequency Receptors KIR Genotype Genetics medicine Humans Distribution (pharmacology) 030216 legal & forensic medicine Receptor Gene Haplotype Public Health Environmental and Occupational Health 030104 developmental biology medicine.anatomical_structure Haplotypes Immunology Function (biology)
Zdroj:	Annals of Human Biology. 48:133-141
ISSN:	1464-5033 0301-4460
Popis:	The killer cell immunoglobulin-like receptor (KIR), which mediates the killing function of NK cells, is an attractive candidate for adoptive cellular therapy. The ethnic distribution for China provides a unique opportunity to investigate KIR gene distribution.The aim of this study was to explore the relationship between population history and the rapidly evolving KIR genetic diversity.8050 Chinese donors from 184 hospitals were included to analyse frequency, haplotype, and B-content data of 16 KIR genes, by PCR-SSP for KIR genotyping.KIR gene carrier frequencies were found similar to those observed in other studies on Han, but different from Thais, Japanese, Africans, and populations of West Eurasian ancestry. High-frequency KIR genotype profiles found in the present population were consistent with other studies on Han populations but different from those conducted on other cohorts. The majority of our cohort carried group A KIR gene motifs. Additionally, populations with similar geographic locations in China were shown clustered together, while Hainan and Xinjiang provinces were slightly separated from these.The distribution of KIR genes varies by geographic region, and different ethnic groups may be a confounding factor of KIR diversity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f5d18ed354d148d5851d21c40250ba https://doi.org/10.1080/03014460.2021.1913223 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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