A Closed-Loop Artificial Pancreas Using a Proportional Integral Derivative with Double Phase Lead Controller Based on a New Nonlinear Model of Glucose Metabolism
| Autor: | Pierre-Yves Richard, I. Guilhem, Marie-Anne Lefebvre, J.-Y. Poirier, Ilham Ben Abbes |
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| Přispěvatelé: | Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire [Rennes], Nantes Université (NU)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Rennes 1 (UR1) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Pancreas Artificial Endocrinology Diabetes and Metabolism Biomedical Engineering PID controller 030209 endocrinology & metabolism Bioengineering Hypoglycemia Nonlinear control Artificial pancreas [SPI.AUTO]Engineering Sciences [physics]/Automatic 03 medical and health sciences User-Computer Interface 0302 clinical medicine Insulin Infusion Systems Control theory Linearization Diabetes mellitus Internal Medicine medicine Humans Lead (electronics) 030304 developmental biology Mathematics 0303 health sciences Diabetes PID Equipment Design medicine.disease Diabetes Mellitus Type 1 Glucose Closed-loop control Original Article Algorithms Nonlinear control model [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Journal of Diabetes Science and Technology Journal of Diabetes Science and Technology, 2013, 7 (3), pp.699-707. ⟨10.1177/193229681300700315⟩ |
| DOI: | 10.1177/193229681300700315⟩ |
| Popis: | Background: Most closed-loop insulin delivery systems rely on model-based controllers to control the blood glucose (BG) level. Simple models of glucose metabolism, which allow easy design of the control law, are limited in their parametric identification from raw data. New control models and controllers issued from them are needed. Methods: A proportional integral derivative with double phase lead controller was proposed. Its design was based on a linearization of a new nonlinear control model of the glucose-insulin system in type 1 diabetes mellitus (T1DM) patients validated with the University of Virginia/Padova T1DM metabolic simulator. A 36 h scenario, including six unannounced meals, was tested in nine virtual adults. A previous trial database has been used to compare the performance of our controller with their previous results. The scenario was repeated 25 times for each adult in order to take continuous glucose monitoring noise into account. The primary outcome was the time BG levels were in target (70–180 mg/dl). Results: Blood glucose values were in the target range for 77% of the time and below 50 mg/dl and above 250 mg/dl for 0.8% and 0.3% of the time, respectively. The low blood glucose index and high blood glucose index were 1.65 and 3.33, respectively. Conclusion: The linear controller presented, based on the linearization of a new easily identifiable nonlinear model, achieves good glucose control with low exposure to hypoglycemia and hyperglycemia. |
| Databáze: | OpenAIRE |
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