INCREASE IN ACCUMULATION OF L-DOPA (3,4-DIHYDROXY-PHENYLALANINE) IN BRAIN SLICES BY ALCOHOL
| Autor: | Kenichi Kaniike, Hiroshi Yoshida |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
Cerebral Cortex
Pharmacology chemistry.chemical_classification Nervous system Carbon Isotopes Ethanol Phenylalanine Research Guinea Pigs Alcohol Metabolism Dihydroxyphenylalanine Amino acid Levodopa chemistry.chemical_compound medicine.anatomical_structure chemistry Biochemistry Cerebral cortex Alcohols medicine Lipotropic Intracellular |
| Zdroj: | Japanese Journal of Pharmacology. 13:292-296 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.13.292 |
| Popis: | In our previous paper it was described that an amino acid, L-dopa (3, 4-dihydroxyphenylalanine) was accumulated in brain slices against concentration gradient and an energy dependent active transport process was assumed to be participated in this phenomenon (1, 4). The carrier system for this active transport of L-dopa was assumed to divide at least into two parts: a specific site to combine with L-dopa and the Na+, K+-activated ATP-ase which seems to play a common important role for many active transport processes. Moreover it was discussed on a role of intracellular K+ concentration in this active transport process (1-4). In this paper, effect of alcohol on accumulation of dopa in brain slices is examined, for alcohol is a typical neurotropic and lipotropic agent and it is assumed that alcohol may exert a certain influence on the phenomenon and it may be possible to get a clue to clarify a mode of action of alcohol on nervous system. |
| Databáze: | OpenAIRE |
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