| Autor: |
Saeid, Amini-Nik, Abdikarim, Abdullahi, Roohi, Vinaik, Ren Jie Robert, Yao, Nancy, Yu, Andrea, Datu, Cassandra, Belo, Marc G, Jeschke |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Aging and disease. 13:540 |
| ISSN: |
2152-5250 |
| DOI: |
10.14336/ad.2021.1008 |
| Popis: |
Impaired wound healing is a major issue in the elderly population and is associated with substantial health and economic burden, which is exponentially increasing with the growing aging population. While the underlying pathobiology of disturbed skin healing by aging is linked to several genetic and epigenetic factors, little is known about the cell-cell interaction during the wound healing process in aged individuals, particularly the mesenchymal stem cell (MSCs)-macrophages axis. In this study, by using a thermal injury animal model in which we compared the wound healing process of adult and young mice, we found that the insufficient pool of MSCs in adult animals are deficient in migrating to the wound bed and instead are restricted to the wound edge. We identified a deficiency of a CD90-positive MSC subpopulation in the wounds of adult animals, which is positively correlated with the number of F4/80+ macrophages. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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